Anti-inflammatory and antidiabetic effects of grape-derived stilbene concentrate in the experimental metabolic syndrome.
Anatolii V KubishkinAlina ShevandovaVitalina PetrenkoIryna I FomochkinaLeya SorokinaAlexander KucherenkoAndrey GordienkoNatalia KhimichEvgeniya Y ZyablitskayaTatiana P MakalishLeonid AlievNatalia KornienkoIvan FomochkinPublished in: Journal of diabetes and metabolic disorders (2020)
The experimentally induced MetS development leads to classic MetS signs, including abdominal obesity, hyperglycemia, high lipid levels and heart damage. The expression of glucose transporter type 4 (GLUT4) and peroxisome proliferator-activated receptor-γ (PPAR-γ) had greater dynamics than biochemical measurements. The development of the associated inflammatory reactions was confirmed by the increased level of Toll-like receptor type 4 (TLR4) and C-reactive protein (CRP) compared to control levels. The use of the GDSC had positive dynamics in carbohydrate and lipid levels, inflammatory marker, also prevented associated inflammation and heart damage.
Keyphrases
- toll like receptor
- oxidative stress
- metabolic syndrome
- diabetic rats
- insulin resistance
- inflammatory response
- nuclear factor
- immune response
- anti inflammatory
- heart failure
- fatty acid
- type diabetes
- weight loss
- binding protein
- high glucose
- uric acid
- adipose tissue
- endothelial cells
- skeletal muscle
- cardiovascular risk factors
- blood glucose