Possible involvement of DExD/H box helicase 60 in synovial inflammation of rheumatoid arthritis: role of toll-like receptor 3 signaling.
Yuzuru NakamuraHikaru Kristi IshibashiTatsuro SarugaTadaatsu ImaizumiAkira KuroseMayuki TachizakiShogo KawaguchiKazuhiko SeyaEiji SasakiYasuyuki IshibashiPublished in: Molecular biology reports (2024)
The synovial DDX60 was more expressed in RA patients than in OA. In human RFLS, DDX60 stimulated by TLR3 signaling affected CXCL10 expression. DDX60 may contribute to synovial inflammation in RA.
Keyphrases
- toll like receptor
- rheumatoid arthritis
- inflammatory response
- nuclear factor
- end stage renal disease
- oxidative stress
- disease activity
- immune response
- ejection fraction
- endothelial cells
- newly diagnosed
- poor prognosis
- chronic kidney disease
- ankylosing spondylitis
- interstitial lung disease
- binding protein
- peritoneal dialysis
- transcription factor
- prognostic factors
- systemic lupus erythematosus
- systemic sclerosis