Effects of hyaluronic acid combined with anti-inflammatory drugs compared with hyaluronic acid alone, in clinical trials and experiments in osteoarthritis: a systematic review and meta-analysis.
Thippaporn EuppayoVeerasak PunyapornwithayaSiriwadee ChomdejSiriwan OngchaiKorakot NganvongpanitPublished in: BMC musculoskeletal disorders (2017)
IA-HA + AI had greater efficacy for pain relief than IA-HA alone within a one-year period. However, HA + AI down-regulated the ACAN gene when compared with HA alone in vitro.
Keyphrases
- hyaluronic acid
- clinical trial
- anti inflammatory drugs
- artificial intelligence
- chronic pain
- rheumatoid arthritis
- pain management
- genome wide
- randomized controlled trial
- neuropathic pain
- gene expression
- machine learning
- open label
- deep learning
- double blind
- study protocol
- genome wide identification
- postoperative pain