12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.

Kaishi SatomiHirokazu TakamiShintaro FukushimaSatoshi YamashitaYuko MatsushitaYoichi NakazatoTomonari SuzukiShota TanakaAkitake MukasaNobuhito SaitoMasayuki KanamoriToshihiro KumabeTeiji TominagaKeiichi KobayashiMotoo NaganeToshihiko IuchiKoji YoshimotoKaoru TamuraTaketoshi MaeharaKeiichi SakaiKazuhiko SugiyamaKiyotaka YokogamiHideo TakeshimaMasahiro NonakaAkio AsaiToshikazu UshijimaMasao MatsutaniRyo NishikawaKoichi Ichimura

Published in: Neuro-oncology (2021)

12p gain may predict the presence of malignant components of NGGCTs, and poor prognosis of the patients. It may be associated with early tumorigenesis of CNS GCT.

Keyphrases

germ cell
poor prognosis
long non coding rna
end stage renal disease
ejection fraction
prognostic factors
peritoneal dialysis
genome wide
clinical trial
dna methylation
open label
phase iii