Complement factor D is linked to platelet activation in human and rodent sepsis.
Oliver SommerfeldK DahlkeM SossdorfR A ClausA ScheragM BauerF BloosPublished in: Intensive care medicine experimental (2021)
In mice, CFD is linked to pronounced platelet activation, depicted by higher GPIIb/IIIa surface expression in wild-type mice. This might be of clinical importance since high CFD plasma concentrations were also associated with increased mortality in sepsis patients.
Keyphrases
- wild type
- end stage renal disease
- acute kidney injury
- intensive care unit
- ejection fraction
- newly diagnosed
- endothelial cells
- high fat diet induced
- chronic kidney disease
- septic shock
- poor prognosis
- prognostic factors
- peritoneal dialysis
- cardiovascular events
- cardiovascular disease
- adipose tissue
- type diabetes
- metabolic syndrome
- binding protein