Sirtuins (SIRTs) As a Novel Target in Gastric Cancer.
Agata Poniewierska-BaranPaulina WariasKatarzyna ZgutkaPublished in: International journal of molecular sciences (2022)
Gastric cancer is a major health burden worldwide. Among all neoplasms, gastric cancer is the fifth most common and the third most deadly type of cancer. It is known that sirtuins (SIRTs), are NAD + -dependent histone deacetylases regulating important metabolic pathways. High expression of SIRTs in the human body can regulate metabolic processes; they prevent inflammation but also resist cell death and aging processes. The seven members of this family enzymes can also play a fundamental role in process of carcinogenesis by influencing cell viability, apoptosis and metastasis. This review collects and discusses the role of all seven sirtuins (SIRT1-SIRT7) in the pathogenesis of gastric cancer (GC).
Keyphrases
- cell death
- oxidative stress
- healthcare
- endothelial cells
- cell cycle arrest
- public health
- ischemia reperfusion injury
- poor prognosis
- dna methylation
- mental health
- endoplasmic reticulum stress
- mass spectrometry
- cell proliferation
- binding protein
- health information
- induced pluripotent stem cells
- long non coding rna
- climate change