Intensive glucose control and recurrent cardiovascular events: 14-year follow-up investigation of the ACCORDION study.

Intensive glucose control may not affect cardiovascular disease progression except in select subgroups. Since time-to-first event analysis may miss beneficial or harmful effects of glucose control on the risk of cardiovascular disease, recurrent events analysis should be routine in cardiovascular outcome trials, particularly when investigating long-term treatment effects. CLINICAL TRIAL REG: no. NCT00000620, clinicaltrials.gov. This article is protected by copyright. All rights reserved.