Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial.

Takashi Sakurai Taiki SugimotoHiroyasu AkatsuTakehiko DoiYoshinori FujiwaraAkihiro HirakawaFumie KinoshitaMasafumi KuzuyaSangyoon LeeNanae MatsumotoKoichiro MatsuoMakoto MichikawaAkinori NakamuraSusumu OgawaRei OtsukaKenji Sato Hiroyuki ShimadaHiroko SuzukiHiroyuki SuzukiHajime TakechiShinya TakedaKazuaki UchidaHiroyuki UmegakiSatomu WakayamaHidenori Arainull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

This trial evaluated the efficacy of multidomain intervention in individuals with MCI. The trial did not show a significant difference in preplanned cognitive outcomes. Interventions had positive effects on a wide range of secondary health outcomes. Those with adequate adherence or high risk of dementia benefited from interventions.

Keyphrases

mild cognitive impairment
study protocol
phase iii
randomized controlled trial
phase ii
clinical trial
cognitive impairment
open label
adipose tissue
metabolic syndrome
skeletal muscle
pain management
glycemic control