Treatment-related adverse events of antibody-drug conjugates in clinical trials: A systematic review and meta-analysis.

Jinming LiGuoshuang ShenZhen LiuYaobang LiuMiaozhou WangFuxing ZhaoDengfeng RenQiqi XieZitao LiZhilin LiuYi ZhaoZongbi YiXinlan LiuZhengbo XuJiuda Zhao

Published in: Cancer innovation (2023)

This study provides a comprehensive overview of AEs related to ADCs used for cancer treatment. ADC use resulted in a high incidence of any-grade AEs but a low incidence of grade ≥ 3 AEs. The AE profiles and incidence differed according to cancer type, ADC type, and ADC components.

Keyphrases

risk factors
clinical trial
diffusion weighted imaging
diffusion weighted
randomized controlled trial
magnetic resonance imaging
squamous cell carcinoma
contrast enhanced
drug delivery
study protocol
smoking cessation