Dietary nitrate prevents progression of carotid subclinical atherosclerosis through blood pressure-independent mechanisms in patients with or at risk of type 2 diabetes mellitus.
Franca MorselliLuca FacontiCharlotte Elizabeth MillsSteven MorantPhillip J ChowienczykJoshua Au YeungAlessandro CavarapeJohn Kennedy CruickshankAndrew James WebbPublished in: British journal of clinical pharmacology (2021)
Our results show that 6 months' intervention with dietary nitrate influences vascular remodelling, but not carotid stiffness or diameter. Neither spironolactone nor doxazosin had a BP-independent effect on carotid structure and function.