Autopsy of a failed trial part 2: Outcomes, challenges, and lessons learnt from the DAISIES trial.
Başak İnceMatthew D PhillipsZohra ZenasniJames ShearerBethan DaltonMadeleine IrishDaniela MercadoHannah WebbCatherine McCombieKatie AuNikola KernSam Clark-StoneFrances ConnanA Louise JohnstonStanimira LazarovaEwa ZadehCiarán NewellTayeem PathanJackie WalesRebecca CashmoreSandra MarshallJon ArcelusPaul RobinsonSarah ByfordSabine LandauVanessa C LawrenceHubertus HimmerichJanet TreasureUlrike H SchmidtPublished in: European eating disorders review : the journal of the Eating Disorders Association (2023)
No conclusions can be drawn concerning the effectiveness of IP-TAU and stepped-care DPT, but the latter was perceived more positively. Patient-related, service-related and systemic factors (COVID-19) contributed to the trial's failure. Lessons learnt can inform future studies.
Keyphrases
- study protocol
- phase iii
- phase ii
- clinical trial
- healthcare
- randomized controlled trial
- mental health
- coronavirus disease
- sars cov
- palliative care
- systematic review
- depressive symptoms
- open label
- case report
- type diabetes
- quality improvement
- metabolic syndrome
- weight loss
- drug induced
- cerebrospinal fluid
- glycemic control