Chimerism and gene therapy - Lessons learned from non-conditioned murine bone marrow transplantation models.
Katerina JazbecMojca JežBoštjan SmrekarSimona MiceskaJasmina-Živa RožmanUrban ŠvajgerJanja ZavršnikTadej MalovrhPrimož RožmanPublished in: European journal of haematology (2018)
By extrapolating our murine data, and data from some previous studies to a human non-conditioned autologous CD34+ HSPC transplantation setting, we conclude that approximately 44 million CD34+ HSPCs would be needed to achieve 20% donor chimerism in a 70-kg human, which could serve as a starting point for the future use of HSCPs in gene and cell therapy.
Keyphrases
- cell therapy
- bone marrow
- gene therapy
- endothelial cells
- mesenchymal stem cells
- stem cells
- electronic health record
- induced pluripotent stem cells
- allogeneic hematopoietic stem cell transplantation
- big data
- pluripotent stem cells
- copy number
- acute lymphoblastic leukemia
- gene expression
- current status
- case control
- deep learning