Associations between childhood maltreatment and oxidative nucleoside damage in affective disorders.
Johanne Kofod Damm EriksenKlara CoelloSharleny StanislausHanne Lie KjærstadKimie Stefanie Ormstrup SletvedRoger S McIntyreMaria Faurholt-JepsenKamilla K MiskowiakHenrik Enghusen PoulsenLars Vedel KessingMaj VinbergPublished in: European psychiatry : the journal of the Association of European Psychiatrists (2022)
Our findings of an association between childhood maltreatment and oxidative stress markers suggest that childhood maltreatment overall, notably emotional abuse and emotional neglect, is associated with enhanced systemic damage to DNA and RNA in adulthood. Further, individuals with AD reported a higher prevalence of childhood maltreatment, which may induce higher levels of nucleoside damage by oxidation in adulthood, possibly leading to increased risk of developing AD. Longitudinal studies are needed to clarify this relationship further.