High-performance liquid chromatography (HPLC) as a means of assessing the presence of uric acid in archeological human remains: Challenges and future directions.
Jo BuckberryRichard TelfordLaura Castells NavarroJohn SnaithDavid SwinsonAndrew HealeyMegan B BrickleyPublished in: American journal of biological anthropology (2024)
The lack of detectable uric acid extracted from these samples suggests that (1) urate crystals were not present in any of the bone samples, regardless of gout status; (2) urate crystals did not survive these specific archeological conditions; or (3) the concentration of uric acid in our bone extracts was low, and thus larger samples would be required.
Keyphrases
- uric acid
- high performance liquid chromatography
- metabolic syndrome
- simultaneous determination
- tandem mass spectrometry
- solid phase extraction
- mass spectrometry
- bone mineral density
- endothelial cells
- ms ms
- room temperature
- soft tissue
- liquid chromatography
- induced pluripotent stem cells
- bone regeneration
- pluripotent stem cells