Metformin induces insulin secretion by preserving pancreatic aquaporin 7 expression in type 2 diabetes mellitus.

Published in: Journal of diabetes investigation (2021)

In the presence of metformin, the c-Jun-NH2-terminal kinase and p38 pathways in β-cells are inhibited, resulting in preserved aquaporin 7 expression and improved glycerol influx, thus maintaining insulin secretion.

Keyphrases

poor prognosis
induced apoptosis
cell cycle arrest
binding protein
cell death
protein kinase
cell proliferation