Identification of neutrophil β2-integrin LFA-1 as a potential mechanistic biomarker in ANCA-associated vasculitis via microarray and validation analyses.

Kotaro MatsumotoTakahiko KurasawaKeiko YoshimotoKatsuya SuzukiTsutomu Takeuchi

Published in: Arthritis research & therapy (2021)

The expression of LFA-1 in neutrophils is increased in patients with AAV. Neutrophil LFA-1 levels correlate with the clinical features of AAV. Inhibiting the adhesion of LFA-1 and ICAM1 impedes the neutrophil-endothelium interaction and may have a therapeutic role in AAV.

Keyphrases

gene therapy
poor prognosis
nitric oxide
signaling pathway
cell migration
biofilm formation
long non coding rna
cell adhesion
binding protein
cystic fibrosis