Anakinra in hospitalized non-intubated patients with coronavirus disease 2019: a Systematic review and meta-analysis.
Haralampos MilionisSebastian Filippas-NtekouanMaria KosmidouEvangelos LiberopoulosAngelos LiontosHaralampos MilionisPublished in: Rheumatology (Oxford, England) (2021)
Available evidence shows that treatment with anakinra reduces both the need for invasive mechanical ventilation and mortality risk of hospitalized non-intubated patients with COVID-19 without increasing the risk of adverse events. Confirmation of efficacy and safety requires randomized placebo-controlled trials.
Keyphrases
- mechanical ventilation
- placebo controlled
- double blind
- coronavirus disease
- acute respiratory distress syndrome
- intensive care unit
- phase iii
- phase ii
- open label
- respiratory failure
- study protocol
- clinical trial
- cardiovascular events
- randomized controlled trial
- squamous cell carcinoma
- risk factors
- coronary artery disease
- cardiovascular disease
- phase ii study
- radiation therapy
- respiratory syndrome coronavirus
- extracorporeal membrane oxygenation
- locally advanced