The importance of inflammatory biomarkers in non-specific acute and chronic low back pain: a systematic review.

Eduardo Moreira Pinto João Rocha Neves Manuel Laranjeira Joaquim L Reis

Published in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2023)

This systematic review found evidence of increased levels of pro-inflammatory biomarkers CRP, IL-6 and TNF-α and decreased levels of anti-inflammatory biomarker IL-10 in patients with LBP. Hs-CRP was not correlated with LBP. There is insufficient evidence to associate these findings with the degree of pain severity or the activity status of the lumbar pain over time.

Keyphrases

systematic review
chronic pain
pain management
anti inflammatory
neuropathic pain
liver failure
meta analyses
rheumatoid arthritis
minimally invasive
randomized controlled trial
spinal cord injury
aortic dissection