PPARγ preservation via promoter demethylation alleviates osteoarthritis in mice.

Xiaobo ZhuFang ChenKe LuAi WeiQing JiangWangsen Cao

Published in: Annals of the rheumatic diseases (2019)

Epigenetic PPARγ suppression plays a key role in OA development and PPARγ preservation via promoter demethylation possesses promising therapeutic potentials in clinical treatment of OA and the related joint diseases.

Keyphrases

dna methylation
knee osteoarthritis
insulin resistance
gene expression
transcription factor
fatty acid
high fat diet induced
rheumatoid arthritis
metabolic syndrome
adipose tissue
combination therapy
skeletal muscle