Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial.
Caoileann H MurphyEllen M FlanaganGiuseppe De VitoDavide SustaKathleen A J MitchelsonElena de Marco CastroJoan M G SendenJoy P B GoessensAgnieszka MikłoszAdrian ChabowskiRicardo SeguradoClare A CorishSinead N McCarthyBrendan EganLuc J C van LoonHelen M RochePublished in: The American journal of clinical nutrition (2021)
Contrary to our hypothesis, we did not observe a beneficial effect of LEU-PRO supplementation alone or combined with LC n-3 PUFA supplementation on appendicular lean mass, strength, physical performance or MyoPS in older adults at risk of sarcopenia. This trial was registered at clinicaltrials.gov as NCT03429491.
Keyphrases
- physical activity
- double blind
- study protocol
- clinical trial
- phase iii
- mental health
- skeletal muscle
- placebo controlled
- phase ii
- randomized controlled trial
- simultaneous determination
- open label
- anti inflammatory
- mass spectrometry
- high resolution
- amino acid
- binding protein
- body composition
- small molecule
- community dwelling
- gas chromatography