Login / Signup

(Mammary Analogue) Secretory Carcinoma of the Nasal Cavity: Report of a Rare Case with p63 and DOG1 Expression and Uncommon Exon 4-Exon 14 ETV6-NTRK3 Fusion Diagnosed with Next Generation Sequencing.

Bingcheng WuThomas Kwok Seng LohTomas VanecekMichal MichalFredrik Petersson
Published in: Head and neck pathology (2019)
We present a 72 years old male with a left nasal cavity (mammary analogue) secretory carcinoma (SC) which exhibited classical morphological features on light microscopical examination, diffuse strong S100 and mammoglobin positivity on immunohistochemistry, and ETV6-NTRK3 gene fusion on next generation sequencing (NGS) analysis. Unusual features of this tumor are expression of p63 and DOG1 on immunohistochemistry and the atypical junction between Exon 4 of the ETV6 gene and Exon 14 of the NTRK3 gene.
Keyphrases
  • copy number
  • acute lymphoblastic leukemia
  • rare case
  • poor prognosis
  • genome wide
  • binding protein
  • dna methylation
  • long non coding rna
  • low grade
  • gene expression
  • chronic rhinosinusitis
  • high grade
  • genome wide analysis