Detection of SARS-CoV-2 infection in the general population by three prevailing rapid antigen tests: cross-sectional diagnostic accuracy study.
Roderick P VenekampIrene K VeldhuijzenKarel G M MoonsWouter van den BijllaardtSuzan D PasEsther B LodderRichard MolenkampZsofia IgloiConstantijn WijersClaudy Oliveira Dos SantosSylvia B DebastMarjan J BruinsKhaled PoladCarla R S Nagel-ImmingWanda G H HanJanneke H H M van de WijgertSusan van den HofEwoud SchuitPublished in: BMC medicine (2022)
Overall sensitivities of three SARS-CoV-2 Ag-RDTs were 69-75%, increasing to ≥86% above a viral load cut-off. The decreased sensitivity among asymptomatic participants and high positivity rate during follow-up in false-negative Ag-RDT participants emphasise the need for education of the public about the importance of re-testing after an initial negative Ag-RDT should symptoms develop. For SD-Biosensor, the diagnostic accuracy with OP-N and deep nasopharyngeal sampling was similar; adopting the more convenient sampling method might reduce the threshold for professional testing.