High glucose-induced injury in human umbilical vein endothelial cells is alleviated by vitamin D supplementation through downregulation of TIPE1.

Zhoujun LiuHaogang SunYu ChenJia HeLin ZhuBing YangWenzhuo Zhao

Published in: Diabetology & metabolic syndrome (2024)

Vitamin D reverses the harmful effects of high glucose on HUVECs by reducing TIPE1 expression. And vitamin D supplementation could help to alleviate high glucose-induced injury in type 2 diabetes mellitus patients with microvascular complications.

Keyphrases

high glucose
endothelial cells
poor prognosis
vascular endothelial growth factor
cell proliferation
signaling pathway
risk factors
long non coding rna
binding protein