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Transformation of Amides to Thioamides Using an Efficient and Novel Thiating Reagent.

Mohamed S GomaaGaber El EnanyWalid FathallaIbrahim A I AliSamir Mohamed El Rayes
Published in: Molecules (Basel, Switzerland) (2022)
A convenient protocol was developed for the transformation of N -aryl-substituted benzamides to N -aryl-substituted benzothioamides using N -isopropyldithiocarbamate isopropyl ammonium salt as a novel thiating reagent. The major advantages of this protocol are its one-pot procedure, short reaction times, mild conditions, simple work-up, high yields and pure products.
Keyphrases
  • molecular docking
  • randomized controlled trial
  • minimally invasive
  • ionic liquid
  • molecular dynamics simulations
  • electron transfer