Signal pathways, diseases, and functions associated with the miR-19a/92a cluster and the use of berberine to modulate the expression of this cluster in multiple myeloma cells.

Zhao YinJuhua YangRong NingYanjun LiuMaoxiao FengChunmin GuJia FeiYumin Li

Published in: Journal of biochemical and molecular toxicology (2018)

Our findings may exhibit that miR-19a/92a cluster is a therapeutic target for MM and provide new mechanistic insight into the anti-MM effects of certain compounds in traditional Chinese herbal medicines.

Keyphrases

long non coding rna
cell proliferation
poor prognosis
multiple myeloma
long noncoding rna
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
binding protein
pi k akt