Self-Assembly of Integrin Ligands on the Apical Membrane Inhibits the Migration of Glioma Cells.

Dingze MangSona Rani RoyHong Huat HohXia WuJiahao ZhangChengzhi JinShijin Zhang

Published in: Langmuir : the ACS journal of surfaces and colloids (2020)

Malignant brain cancer remains challenging in treatment due to the highly invasive quality of gliomas. Inspired by the upregulated expression of integrin β1 subunits in tumors, we designed and synthesized an integrin-targeting self-assembling ligand based on a laminin-derived peptide that selectively forms nanofibrous microdomains on the apical membrane of glioma cells, inhibiting their migration and invasion.

Keyphrases

cell adhesion
poor prognosis
cell migration
papillary thyroid
high grade
white matter
signaling pathway
resting state
functional connectivity
squamous cell carcinoma
binding protein
multiple sclerosis
quality improvement
young adults
lymph node metastasis
smoking cessation