Medical treatment of SUNCT and SUNA: a prospective open-label study including single-arm meta-analysis.

Giorgio LambruAnker StubberudKhadija RantellSusie LagrataErling TronvikManjit Singh Matharu

Published in: Journal of neurology, neurosurgery, and psychiatry (2020)

We propose a treatment algorithm for SUNCT and SUNA for clinical practice. The response to sodium channel blockers indicates a therapeutic overlap with trigeminal neuralgia, suggesting that sodium channels dysfunction may be a key pathophysiological hallmark in these disorders. Furthermore, the therapeutic similarities between SUNCT and SUNA further support the hypothesis that these conditions are variants of the same disorder.

Keyphrases

systematic review
open label
clinical practice
healthcare
clinical trial
oxidative stress
squamous cell carcinoma
randomized controlled trial
gene expression
angiotensin converting enzyme
phase ii study
neural network