Monocyte-derived Dll4 is a novel contributor to persistent systemic inflammation in HIV patients.
Shumin WangMeera SinghHongmei YangCraig N MorrellLaith Awad MohamadJasmine Jiayuan XuTiffany NguyenSara TureAlicia TyrellSanjay B MaggirwarGiovanni SchifittoJinjiang PangPublished in: bioRxiv : the preprint server for biology (2023)
Pro-inflammatory stimuli increase Dll4 expression and Dll4-Notch1 signaling activation in monocytes and enhance monocyte proinflammatory phenotype, contributing to persistent systemic inflammation in male and female PLWH. Therefore, monocyte mDll4 could be a potential biomarker and therapeutic target of systemic inflammation. Plasma exDll4 may also play an additional role in systemic inflammation but primarily in men.