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Novel insight into FCSK-congenital disorder of glycosylation through a CRISPR-generated cell model.

Maryam Fazelzadeh HaghighiHossein Jafari KhamiraniJafar FallahiAli Arabi MonfaredKorosh Ashrafi DehkordiSeyed Mohammad Bagher Tabei
Published in: Molecular genetics & genomic medicine (2024)
This study expands insight into the FCSK-CDG molecular mechanism; to the best of our knowledge, it is the first research conducted to reveal a gene whose expression level alters due to this disease.
Keyphrases
  • genome wide
  • single cell
  • poor prognosis
  • healthcare
  • dna methylation
  • crispr cas
  • copy number
  • cell therapy
  • gene expression
  • bone marrow
  • mesenchymal stem cells
  • transcription factor