Cohort-specific imputation of gene expression improves prediction of warfarin dose for African Americans.

Assaf GottliebRoxana DaneshjouMarianne DeGorterStephane BourgeoisPeter J SvenssonMia WadeliusPanos DeloukasStephen B MontgomeryRuss B Altman

Published in: Genome medicine (2017)

Our results demonstrate that imputed expression can improve dose prediction and bridge population-specific compositions. MATLAB code is available at https://github.com/assafgo/warfarin-cohort.

Keyphrases

gene expression
atrial fibrillation
venous thromboembolism
direct oral anticoagulants
poor prognosis
dna methylation
oral anticoagulants
binding protein
long non coding rna