IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts.

Eleonora Adami Sivakumar ViswanathanAnissa A WidjajaBenjamin NgSonia ChothaniNevin ZhihaoJessie TanPei Min LioBenjamin L GeorgeUmut AltunogluKakaly GhoshBhairav S PalejaSebastian SchaferBruno ReversadeSalvatore AlbaniAndrea Low Hsiu LingSteven O'Reilly Stuart Alexander Cook

Published in: Rheumatology (Oxford, England) (2021)

These data reveal that autocrine IL11-dependent ERK activity alone or downstream of TGFβ stimulation promotes fibrosis phenotypes in dermal fibroblasts and suggest IL11 as a potential therapeutic target in SSc.

Keyphrases

systemic sclerosis
signaling pathway
interstitial lung disease
cell proliferation
transforming growth factor
pi k akt
electronic health record
gene expression
genome wide
single cell
big data
wound healing
data analysis