Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer.

Ali AlhuseinalkhudhurMark LubberinkHenrik LindmanVladimir TolmachevFredrik Y FrejdJoachim FeldwischIrina VelikyanJens Sörensen

Published in: EJNMMI research (2020)

68Ga-ABY-025 binding in HER2-positive metastases was well characterized by irreversible two-tissue compartment model wherein Ki highly correlated with SUVs at 2 and 4 h. Dynamic scanning with parametric image formation can be used to evaluate metastatic HER2 expression accurately.

Keyphrases

metastatic breast cancer
pet ct
binding protein
poor prognosis
squamous cell carcinoma
small cell lung cancer
dna binding
computed tomography
positron emission tomography
high resolution
deep learning
neoadjuvant chemotherapy
transcription factor
electron microscopy