Dermatophagoides pteronyssinus allergen Der p 22: Cloning, expression, IgE-binding in asthmatic children, and immunogenicity.
Ying ZhouLin LiZhiwei YuXiaohong GuRuilin PanQingqing LiCunyin YuanFangfang CaiYimin ZhuYu-Bao CuiPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2022)
Recombinant Der p 22 exhibited high IgE-binding rates in allergic children, indicating the activity of the recombinant protein and suggesting this novel allergen may be appropriate for inclusion in an allergy diagnostic workup. This finding is supported by in vitro and mouse in vivo studies showing rDer p 22 induced strong allergenic reactivity and apoptosis.
Keyphrases
- binding protein
- young adults
- allergic rhinitis
- poor prognosis
- oxidative stress
- endoplasmic reticulum stress
- cell death
- diabetic rats
- high glucose
- dna binding
- cell free
- atopic dermatitis
- chronic obstructive pulmonary disease
- cell proliferation
- small molecule
- endothelial cells
- amino acid
- protein protein
- infectious diseases