Threshold definitions for significant change on the timed 25-foot walk and 9-hole peg test in primary progressive multiple sclerosis.

The traditional ≥ 20% change threshold for the T25FW and NHPT represents a reasonable compromise between reducing the number of false and achieving the largest number of change events in people with PPMS. Our analyses inform the design of clinical trials in PPMS. This article is protected by copyright. All rights reserved.