A Pooled Analysis of Treatment-Free Survival in Advanced Renal Cell Carcinoma.

Elaine Chang Jiaxi Zhou Chi Song Haley Gittleman Laura L Fernandes Chana Weinstock Michael B Atkins Sundeep Agrawal Rajeshwari Sridhara Nicole J Gormley Shenghui Tang Daniel L Suzman Laleh Amiri-Kordestani Paul G Kluetz Richard Pazdur Brian I Rini David F McDermott Meredith M Regan

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

In this post hoc partitioned survival analysis, TFS and TFS without toxicity appeared similar in the IO-TKI group compared with the SUN group. These findings may reflect contin-uation of TKI until progression per protocol design in all trials and discontinuation of IO after 2 years in two trials. See related commentary by Stadler and Karrison, p. 3098.

Keyphrases

free survival
renal cell carcinoma
tyrosine kinase
advanced non small cell lung cancer
randomized controlled trial
oxidative stress
combination therapy
replacement therapy
data analysis