The Temperature-Dependent Effectiveness of Platinum-Based Drugs Mitomycin-C and 5-FU during Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Colorectal Cancer Cell Lines.
Roxan F C P A HeldermanDaan R LökeJan VerhoeffHans M RodermondGregor G W van BochoveMenno BoonSanne van KesterenJuan J Garcia VallejoH Petra KokPieter J TanisNicolaas A P Klaas FrankenJohannes CrezeeArlene L OeiPublished in: Cells (2020)
Our in vitro results demonstrate that a 60-min exposure of platinum-based drugs and MMC are effective in treating 2D and 3D CRC cell cultures, where platinum-based drugs require hyperthermia (>41 °C) to augment effectivity, suggesting that they are, in principle, suitable for HIPEC.