The direct binding of bioactive peptide Andersonin-W1 to TLR4 expedites the healing of diabetic skin wounds.
Chao LiYuxin XiongZhe FuYuxin JiJiayi YanYan KongYing PengZeqiong RuYubing HuangYilin LiYing YangLi HeJing TangYing WangMeifeng YangPublished in: Cellular & molecular biology letters (2024)
AW1 modulates inflammation and the wound healing process by the TLR4/NF-κB molecular axis, thus facilitating reepithelialization, granulation regeneration, and angiogenesis. These findings not only provided a promising multifunctional prohealing drug candidate for chronic nonhealing skin wounds but also highlighted the unique roles of "small" peptides in the elucidation of "big" human disease mechanisms.
Keyphrases
- wound healing
- toll like receptor
- inflammatory response
- endothelial cells
- nuclear factor
- oxidative stress
- immune response
- lps induced
- signaling pathway
- drug delivery
- big data
- induced pluripotent stem cells
- stem cells
- drug induced
- pluripotent stem cells
- cancer therapy
- pi k akt
- emergency department
- dna binding
- type diabetes
- transcription factor
- amino acid
- adverse drug
- metal organic framework
- electronic health record