Negative Regulation of Osteoclast Commitment by Intracellular Protein Phosphatase Magnesium-Dependent 1A.

Oh Chan KwonBongkun ChoiEun-Jin LeeJi-Eun ParkEun-Ju LeeEun-Young KimSang-Min KimMin-Kyung ShinTae Hwan KimSeokchan HongChang-Keun LeeBin YooWilliam H RobinsonYong-Gil KimEun-Ju Chang

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

The loss of PPM1A function in osteoclast precursors driven by inflammatory signals contributes to osteoclast lineage commitment and differentiation by elevating RANK expression, reflecting a potential role of PPM1A in dynamic bone metabolism in axial SpA.

Keyphrases

bone loss
poor prognosis
cell fate
binding protein
oxidative stress
bone mineral density
single cell
human health
soft tissue
protein protein
risk assessment
reactive oxygen species