Overlaid Transcriptional and Proteome Analyses Identify Mitotic Kinesins as Important Targets of Arylsulfonamide-Mediated RBM39 Degradation.

Seemon Coomar Pedro Mota Alexander V Penson Juerg Schwaller Omar Abdel-Wahab Dennis Gillingham

Published in: Molecular cancer research : MCR (2023)

Our approach provides a workflow for identifying and studying the most strongly modulated proteins when splicing is altered. The work also uncovers a splicing-based approach toward pharmacologic targeting of mitotic kinesins.

Keyphrases

cell cycle
transcription factor
gene expression
cancer therapy
cell proliferation
electronic health record