"Thank you for that experience and for the ways it continues to shape who I am and how I interact in all of my life." (S20). There has been limited research validating Clinical Pastoral Education (CPE) as a learning approach to date, however, the anecdotal evidence supporting the transformative value of CPE is abundant, as demonstrated by this student response. This quality improvement project engages a thematic cross-sectional analysis of 34 students' self-evaluative responses reporting the lasting impact of their CPE training. From the survey responses a thematic map was developed highlighting six themes of lasting impact: Spirituality, Psychotherapy, Agency, Self-Inter, Self-Intra, and Story/Narrative. These six themes overlap and intersect to provide a point of what we call "SPE alchemy"-the perfect conditions for lasting impact and transformation.