Biomarkers of cytokine storm as red flags for severe and fatal COVID-19 cases: A living systematic review and meta-analysis.

Ana Karla G MeloKeilla M MilbyAna Luiza M A CaparrozAna Carolina Pereira Nunes PintoRodolfo R P SantosAline P RochaGilda A FerreiraViviane A SouzaLilian D A ValadaresRejane M R A VieiraGecilmara S PileggiVirgínia F M Trevisani

Published in: PloS one (2021)

This review points to interleukin-6, ferritin, leukocytes, neutrophils, lymphocytes, platelets, C-Reactive Protein, procalcitonin, lactate dehydrogenase, aspartate aminotransferase, creatinine, and D-dimer as important biomarkers of cytokine storm syndrome. Elevated levels of interleukin-6 and hyperferritinemia should be considered as red flags of systemic inflammation and poor prognosis in COVID-19.

Keyphrases

poor prognosis
coronavirus disease
sars cov
long non coding rna
peripheral blood
respiratory syndrome coronavirus
case report
uric acid
drug induced