ALSUntangled #63: ketogenic diets.
Richard BedlackPaul E BarkhausBenjamin BarnesMorgan BeauchampTulio BertoriniMark B BrombergGregory T CarterVinay ChaudryMerit CudkowiczCe JacksonGleb LevitskyIsaac LundChristopher J McDermottSteven NovellaNatasha OlbyLyle OstrowGary L PatteeTerry Heiman-PattersonDylan RatnerKristiana SalmonSusan StevesMark TerrelongePaul WicksAnne-Marie WillsPublished in: Amyotrophic lateral sclerosis & frontotemporal degeneration (2021)
ALSUntangled reviews alternative and off label treatments with a goal of helping patients make more informed decisions about them. Here we review ketogenic diets. We shows that these have plausible mechanisms, including augmenting cellular energy balance and reducing excitotoxicity, neuroinflammation and oxidative stress. We review a mouse model study, anecdotal reports and trials in ALS and other diseases. We conclude that there is yet not enough data to recommend ketogenic diets for patients with ALS, especially in light of the many side effects these can have.
Keyphrases
- weight loss
- oxidative stress
- mouse model
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- peritoneal dialysis
- emergency department
- dna damage
- randomized controlled trial
- electronic health record
- systematic review
- ischemia reperfusion injury
- lps induced
- blood brain barrier
- artificial intelligence
- patient reported outcomes
- subarachnoid hemorrhage
- data analysis
- cerebral ischemia
- diabetic rats
- heat shock protein