Radixin Relocalization and Nonmuscle α-Actinin Expression Are Features of Remodeling Cardiomyocytes in Adult Patients with Dilated Cardiomyopathy.
Ayse CetinkayaBenedikt BergeBedriye Sen-HildKerstin TroidlPraveen GajawadaNatalia KubinKlaus ValeskeDietmar SchranzHakan AkintürkMarkus SchönburgThomas KubinYeong-Hoon ChoiManfred RichterPublished in: Disease markers (2020)
Remodeling was similar in ARC and in cardiomyocytes of DCM suggesting evolutionary conserved mechanisms of regeneration. Despite activation of fetal genes, the atrophy of ARC indicates differences in their regenerative capacity from NRC. Cardiac-derived factors induced NM-actinin expression and increased survival of ischemic ARC while circulating molecules were less effective. Identification of these cardiac-derived factors and determination of their individual capacity to heal or damage are of particular importance for a biomarker-guided therapy in adult patients.
Keyphrases
- poor prognosis
- stem cells
- high glucose
- left ventricular
- genome wide
- binding protein
- bioinformatics analysis
- cell therapy
- transcription factor
- photodynamic therapy
- drug induced
- molecularly imprinted
- bone marrow
- ischemia reperfusion injury
- gene expression
- solid phase extraction
- free survival
- mass spectrometry
- subarachnoid hemorrhage
- stress induced
- liquid chromatography
- genome wide analysis