Membrane and Soluble CD137 in Systemic Lupus Erythematosus: Role as Biomarkers for Disease Activity.
Fulvia CeccarelliFrancesco NatalucciAlessandra Di FilippoGiulio OlivieriChiara NapoletanoAurelia RughettiMarianna NutiIlaria Grazia ZizzariFabrizio ContiPublished in: Journal of immunology research (2023)
Our results suggest a possible involvement of CD137-CD137L axis in SLE pathogenesis, as demonstrated by higher expression of CD137 on CD4+ cells in SLE compared with HS. Furthermore, the positive correlation between SLEDAI-2K and membrane CD137 expression on CD4+ cells, as well as soluble CD137, indicates a possible use as biomarkers for disease activity.