Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death.
Arturo Roca-RivadaSandra Marín-CañasMaikel Luis ColliChiara VinciToshiaki SawataniLorella MarselliGabriel SantosPiero MarchettiDecio L EizirikPublished in: Diabetologia (2023)
We show that the type 1 diabetes candidate gene PTPN2 is a key regulator of the deleterious effects of TNF-α in human beta cells. It is conceivable that people with type 1 diabetes carrying risk-associated PTPN2 polymorphisms may particularly benefit from therapies inhibiting TNF-α.
Keyphrases
- type diabetes
- endothelial cells
- rheumatoid arthritis
- induced pluripotent stem cells
- genome wide
- induced apoptosis
- high glucose
- pluripotent stem cells
- copy number
- cardiovascular disease
- glycemic control
- oxidative stress
- signaling pathway
- single cell
- genome wide identification
- cell therapy
- insulin resistance
- gene expression
- transcription factor
- cell cycle arrest
- mesenchymal stem cells
- bone marrow
- endoplasmic reticulum stress
- genome wide analysis
- cell proliferation