Unraveling the effectiveness of antibiotics for peri-implantitis treatment: A scoping review.

Magda Gomes FeresRodrigo MartinsJoão Gabriel Silva SouzaMartinna BertoliniValentim Adelino Ricardo Barão Jamil Awad Shibli

Published in: Clinical implant dentistry and related research (2023)

There are insufficient data to support a particular evidence-based antibiotic protocol to treat peri-implantitis using surgical or nonsurgical therapy, but some conclusions may be drawn. Systemic MTZ adjunct to ultrasonic debridement is an effective protocol to improve the outcomes of nonsurgical treatment. Future studies should assess the clinical and microbiological effects of MTZ and MTZ + AMX as adjuncts to optimal nonsurgical implant decontamination protocols or open-flap debridement. In addition, new locally delivered drugs and antibiotic-loaded surfaces should be assessed by RCTs.

Keyphrases

randomized controlled trial
systematic review
drug delivery
stem cells
escherichia coli
combination therapy
metabolic syndrome
mesenchymal stem cells
adipose tissue
staphylococcus aureus
artificial intelligence
cell therapy
data analysis