Serum miR-379 expression is related to the development and progression of hypercholesterolemia in non-alcoholic fatty liver disease.

Kinya OkamotoMasahiko KodaToshiaki OkamotoTakumi OnoyamaKenichi MiyoshiManabu KishinaTomomitsu MatonoJun KatoShiho TokunagaTakaaki SugiharaAkira HiramatsuHideyuki HyogoHiroshi TobitaShuichi SatoMiwa KawanakaYuichi HaraKeisuke HinoKazuaki ChayamaYoshikazu MurawakiHajime Isomoto

Published in: PloS one (2020)

Serum miR-379 exhibits high potential as a biomarker for NAFLD. miR-379 appears to increase cholesterol lipotoxicity, leading to the development and progression of NAFLD, via interference with the expression of target genes, including those related to the IGF-1 signaling pathway. Our results could facilitate future research into the pathogenesis, diagnosis, and treatment of NAFLD.

Keyphrases

long non coding rna
poor prognosis
cell proliferation
long noncoding rna
signaling pathway
pi k akt
binding protein
genome wide
gene expression
type diabetes
cardiovascular disease
epithelial mesenchymal transition
dna methylation
transcription factor
induced apoptosis
climate change
human health
drug induced