Neural basis of induced phantom limb pain relief.
Sanne KikkertMelvin MezueJacinta O'SheaDavid Henderson SlaterHeidi Johansen-BergIrene TraceyTamar R MakinPublished in: Annals of neurology (2019)
The observed correlation between PLP relief and decreased S1/M1 activity confirms our previous findings linking PLP with increased S1/M1 activity. Our results further highlight the driving role of the mid- and posterior insula, as well as S2, in modulating PLP. Lastly, our novel PLP intervention using task-concurrent NIBS opens new avenues for developing treatment for PLP and related pain conditions. ANN NEUROL 2019;85:59-73.