Malignant ulcer: a great mimicker of gastric plasmablastic lymphoma.
Syamim JohanAllim KhairuddinAsyraf Mohd ZukiWei Woon TengFirdaus HayatiAung MraNornazirah AzizanPublished in: Clinical journal of gastroenterology (2021)
Plasmablastic lymphoma (PBL) is an uncommon human immunodeficiency virus (HIV)-associated lymphoma, with a predilection to develop in the oral cavity. It usually has a plasmablastic morphology with weak or no expression of B cell-associated markers. Among non-HIV patients, it tends to occur in the gastrointestinal (GI) tract, lymph nodes, and skin. We experience a 74-year-old male who presented with abdominal discomfort, altered bowel habit, loss of weight, and loss of appetite with a palpable abdominal mass. Upper endoscopy revealed multiple dish-like and raised nodular mass with a central ulcer in the stomach and duodenum. The histology was consistent with high-grade lymphoma of the plasmablastic type. The immunohistochemistry was positive for plasma cells marker of CD38 and CD138, but negative for the lymphocytic marker of CD45, as well as mature T and B cell marker of CD3 and CD20. Unfortunately, the patient succumbed due to sepsis without completion of his investigations and treatments.
Keyphrases
- human immunodeficiency virus
- antiretroviral therapy
- hepatitis c virus
- diffuse large b cell lymphoma
- hiv infected
- hiv positive
- high grade
- lymph node
- nk cells
- intensive care unit
- hiv testing
- newly diagnosed
- body mass index
- ejection fraction
- men who have sex with men
- oxidative stress
- induced apoptosis
- low grade
- physical activity
- poor prognosis
- south africa
- early stage
- patient reported outcomes
- cell death
- signaling pathway
- single cell
- weight gain
- septic shock
- long non coding rna