Consumption of Diet Soda Sweetened with Sucralose and Acesulfame-Potassium Alters Inflammatory Transcriptome Pathways in Females with Overweight and Obesity.
Allison C SylvetskySabyasachi SenPatrick MerkelFiona DoreDavid B SternCurtis J HenryHongyi CaiPeter J WalterKeith A CrandallKristina I RotherMonica J HubalPublished in: Molecular nutrition & food research (2020)
Consumption of diet soda with sucralose and Ace-K alters inflammatory transcriptomic pathways (e.g., NF-κB signaling) in subcutaneous adipose tissue but does not significantly alter circulating biomarkers. Findings highlight the need to examine molecular and metabolic effects of LCS exposure in a larger randomized control trial for a longer duration.
Keyphrases
- adipose tissue
- oxidative stress
- physical activity
- single cell
- weight loss
- rna seq
- signaling pathway
- double blind
- open label
- gene expression
- insulin resistance
- lps induced
- placebo controlled
- high fat diet
- angiotensin converting enzyme
- single molecule
- pi k akt
- type diabetes
- clinical trial
- nuclear factor
- skeletal muscle
- randomized controlled trial
- inflammatory response
- immune response
- dna methylation